Adult psd

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Membrane-associated guanylate kinases MAGUKs assemble protein complexes at sites of cell-cell contact. However, NMDA receptors are not restricted to the PSDs, as electron microscopic immunocytochemical EM-ICC results indicate that NMDA receptors also occur at nonsynaptic portions of dendrites, perhaps functioning as reserves for rapid insertion into synaptic membranes in response to appropriate synaptic activity. NMDA receptors also occur in axons, at least in part to support glutamate-dependent enhancement of transmitter release. Quantitative analysis revealed that the density of PSD over thick PSDs of asymmetric axo-spinous synaptic junctions is fold the level in the immediately adjacent cytoplasm of spines and terminals, while symmetric synapses show no association with PSD
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